Effect of antisense c-myc oligodeoxynucleotides on intimal hyperplasia of vein autografts of rats

Objective To study the inhibitory effect of antisense c-myc oligodeoxynucleotides on intimal hyperplasia of vein autografts. Methods Antisense c-myc oligodeoxynucleotides of different concentrations, which was dissolved in 30 % pluronic F127 gel solution, was applied around the transplanted vein adventitia. The samples were got 1 and 2 weeks after operation to measure the thickness and observe the expression of c-myc protein in intima. Results At the first week and second week postoperatively, the thickness of vein intima and the c-myc protein expression index were obviously inhibited in a dose-dependent manner in the antisense group as compared with that in the control groups ( P 0.01). But in the groups of F127 or sense oligodeoxynucleotides only no inhibitory effects were found. Conclusions Antisense c-myc oligodeoxynucleotides can inhibit intimal hyperplasia of rat vein autografts in a dose-dependent manner, which was contributed to the decrease of the expression of c-myc protein in intima.\;