The Purpose of Serum Adiponectin Level in Essential Hypertension Patients

Objective To explore the effect of serum adiponectin in essential hypertension(EH) patients and analysis the relationship between serum adiponectin level and cardiovascular risks.Methods ①The study population consisted of 60 EH patients presented to affi liated hospital of Weifang medical university and 60 men matched according to body mass index(BMI), age and sex as controls.②Serum levels of adiponectin were assessed with enzyme linked immunosorbent assay(ELISA).Ambulatory blood pressure monitoring(ABPM) were recorded and other regular clinical and laboratory datas were assessed.Results ①Female exhibited higher serum adiponectin level than male, but this difference is not signif icant(P0.05).②Subjects with EH compared with controls exhibited lower lg(adiponetin) values(P0.01).In the EH group, there was a negative correlation of lg(adiponectin) with BMI, waist-to-hip ratio(WHR), age, 24-hour mean systolic blood pressure, 24-hour mean diastolic blood pressure, 24-hour mean blood pressure.Excluded weight, these relations still existed, though not so closely.Multiple regression analysis showed that 24-hour mean blood pressure, BMI, age were independent predictors of lg(adiponectin) in the EH group.Subjects who had EH had abnormal circadian rhythm of blood pressure.Serum adiponectin between dipper EH and non-dipper EH had no signifi cant difference(P0.05).Conclusion ①Hypoadiponectinemia has relationships with the pathogenesis and development of EH.② There was a negative correlation of serum adiponectin levels with age, BMI, WHR, 24-hour mean systolic blood pressure, 24-hour mean diastolic blood pressure, 24-hour mean blood pressure.And 24-hour mean blood pressure, BMI, age were independent predictors of serum adiponectin levels.