2009•Unpublished venueRequires access
The effect of fluvastatin on serum concentration of resistin in patients with chronic heart failure
Zhen Yao
Open publisher page 1 citations
Abstract
Objective:To observe the effect of fluvastatin on serum concentration of resistin in patients with chronic heart failure(CHF).Methods:49 subjects were divided into two groups:CHF control group(n=25) and CHF treatment group(n=24).Patients in both the CHF control group and the CHF treatment group were given conventional medicine treatment.Patients in the CHF treatment group were given orally fluvastatin(20 mg/day) for eight weeks besides conventional medicine treatment.Left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVDd),6-minute walking distance and resistin were evaluated in all patients before and after treatment.Results:(1) Compared to those before treatment,LVEF and 6-minute walking distance increased(P0.05)and LVDd and resistin decreased(P0.01)after treatment in both the CHF control group and the CHF treatment group.(2) After treatment for 8 weeks,LVEF,LVDd,6-minute walking distance and resistin in the CHF treatment group were significantly different compared to those in the CHF control group.Conclusion:Fluvastatin can improve heart function and lower serum concentration of resistin.