The Distribution of Lipoprotein. Lipase Gene Polymorphisms in Patient with Coronary Hear Disease

Aim Whether the mutation of lipoprotein lipase (LPL) gene is associated with coronary heart disease (CHD) or not has been yet knon We study rela-tionship between mutation in intro 6(PvuⅡ) and 8region of LPL gene and CHDMethods We analysed 106 patients in myocardial infarction survivors through a case-control study.The technique of lpoymerase chain reaction (PCR)-re-striction fragment lengths polymorphism(RFLP)was useh to analysed the genotype of LPL gene.23 fac-tors maybe involved in CHD was chosed. Simple and multiple non-conditioned logistic regression analysis demostrated that 6factors were association with CHD.Results The risk factors were diabetes, smoke,hypertension,LPL GENOTYPE pvu ⅡP P and haplo-type H+ P-. While Apo A/B ratio was regarded as a protective factor.Conclusion LPL genotype Pvu P-P- or H+P- oth-er than the standard risks was contribuing to CHD.