Clinical Controlled Study on Quetiapine and Clozapine Combined with Iithium in Patients with Mania

OBJECTIVE To compare the efficacy and side effects of quetiapine and clozapine both combined with lithium in patients with mania.METHODS Sixty patients meeting the criteria of CCMD-3 for maina were randomly divided into two groups(n=30),which was assigned to receive quetiapine or clozapine both combined with lithium for 6 weeks .Clinical efficacy was evaluated with Bech-Rafaelsen mania rating scale(BRMS) and resistance was evaluated with treatment emergent symptom scale(TESS) and related examinations affiliated to the study.RESULTS The scores of BRMS of the two control groups showed quite significantly difference before and after treatment,while the rate of efficiency was comparative . The time of taking into effect in quetiapine group was later than that in clozapine group,but quetiapine showed slighter side effects and compliance was better compared with clozapine.CONCLUSION It is suggested that quetiapine combined with lithium is as effective as clozapine combined with lithium in patients with mania,and easily accepted by patients because of higher security and better compliance,though the time of taking into effect is later.