The differences between anti-acid and bactericidal treatments in duodenal ulcer

AIMS To study the differences between the antibacterial therapy, losec(omeprazole) and ranitidine in the treatment of duodenal ulcer (DU).METHODS The urease test, Helicobacter pylori scores histologically, the improvement of inflammation in the antrum and duodenum, and the electric microscopy study on the tissue around the ulcer were studied in 64 patients with DU before and after 4 weeks of treatment. RESULTS In the clearance of Helicobacter pylori (for urease test positive rates 100%→9%, 88%→54%, 89%→89%) and the recovery of tissue pathology (for inflammation scores around the ulcer, 2.9±0. 1 →1.8±0.2, 2.6±0.2→2.6±0.3, 2.7±0.3→2.6±0.2), the antibacterial therapy group achieved the best result, the losec group second and ranitidine group did not achieve changes markedly. CONCLUSIONS Owing to Helicobacter pylori clearance, the antibacterial therapy can achieve the better ulcer healing quality which may decrease the relapse rate. Losec can inhibit the Helicobacter pylori activity, but doesn't destroy the bacteria.