Clinical study on Jianwei Yuyang Tablets in treating diabetic gastroparesis

AIM: To investigate the clinical effects and mechanism of Jianwei Yuyang Tablets in treating diabetic gastroparesis. METHODS: Ninety diabetic gastroparesis patients were randomly assigned to 3 groups.Besides conventional hypoglycemic treatment,30 patients in the treated group were given Jianwei Yuyang Tablets and 30 patients in the control group were given domperidone additionally,while 30 patients in the blank group,no additional drug was given.The clinical efficacy and the changes in level of motilin and gastric emptying rate were observed. RESULTS: Jianwei Yuyang Tablets showed significant change in improving clinical symptoms of patients,increasing gastric emptying rate,promoting gastrointestinal kinetics,shortening gastric emptying time,which was beneficial to the control of blood sugar,including the 2 h postprandial blood sugar and fructosamine.The curative rate and total effective rate in the treated group were 63.33%(19/30) and 93.33%(29/30) respectively,significantly different to those in the control group 26.67% (8/30) and 63.33%,also different to those in the blank group 23.33%(3/30) and 10.00%,respectively(P0.01).The clinical efficacy in the treated group was superior to that in the other two groups. CONCLUSION: Jianwei Yuyang Tablets has favorable therapeutic efficacy in treating patients with diabetic gastroparesis.