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2009•Journal of International Reproductive Health/Family PlanningRequires access

Clinical Application and Research Progress of Prostate Specific Membrane Antigen

Cui Yu-gu

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Abstract

Prostate Specific Membrane antigen (PSMA) is one of type Ⅱtransmembrane glycoproteins, with higher tissue specificity and membrane connectivity. There were PSMA expressions in the epithelial cells of normal and malignant prostate, as well as the endothelial cells of new capillaries in many malignant solid tumors originated from no-prostate tissue, while very low expression in the other normal tissues. The expression of PSMA was higher in prostatic cancer, especially the hormone-independent prostatic cancer and its metastasis. In recent years, studies on the clinical application of PSMA targeted diagnosis and treatment developed quickly.

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What this paper is about

Prostate Specific Membrane antigen (PSMA) is one of type Ⅱtransmembrane glycoproteins, with higher tissue specificity and membrane connectivity. There were PSMA expressions in the epithelial cells of normal and malignant prostate, as well as the endothelial cells of new capillaries in many malignant solid tumors originated from no-prostate tissue, while very low expression in the other normal tissues. The expression of PSMA was higher in prostatic cancer, especially the hormone-independent prostatic cancer and its metastasis. In recent years, studies on the clinical application of PSMA targeted diagnosis and treatment developed quickly.

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Available abstract

Prostate Specific Membrane antigen (PSMA) is one of type Ⅱtransmembrane glycoproteins, with higher tissue specificity and membrane connectivity. There were PSMA expressions in the epithelial cells of normal and malignant prostate, as well as the endothelial cells of new capillaries in many malignant solid tumors originated from no-prostate tissue, while very low expression in the other normal tissues. The expression of PSMA was higher in prostatic cancer, especially the hormone-independent prostatic cancer and its metastasis. In recent years, studies on the clinical application of PSMA targeted diagnosis and treatment developed quickly.

Key concepts: Glutamate carboxypeptidase II, Prostate cancer, Prostate, Metastasis, Antigen, Transmembrane protein, Medicine, Glycoprotein

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