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2015•Xiandai shengwu yixue jinzhanRequires access

MiRNA-221/222 Involvement in Hepatocarcinoma

Cui Qing-y

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Abstract

The role of mircroRNAs(mi RNAs) in human tumorigenesis has been demonstrated by gene profiling and functional studies in hepatocellular carcinoma(HCC). Their aberrant expression revealed relations shared with other types of cancer,namely the up-regulation of miR-221/222. MiR-221/222 are two highly homologous microRNAs, whose upregulation has been obviously showed in HCC, which also has been considered to act as oncogenes. Here we will review the role of miR-221/222 in molecule and biomechanism,and explore the possibility of their use as new prognostic and therapeutic tools in HCC.

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What this paper is about

The role of mircroRNAs(mi RNAs) in human tumorigenesis has been demonstrated by gene profiling and functional studies in hepatocellular carcinoma(HCC). Their aberrant expression revealed relations shared with other types of cancer,namely the up-regulation of miR-221/222. MiR-221/222 are two highly homologous microRNAs, whose upregulation has been obviously showed in HCC, which also has been considered to act as oncogenes. Here we will review the role of miR-221/222 in molecule and biomechanism,and explore the possibility of their use as new prognostic and therapeutic tools in HCC.

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Available abstract

The role of mircroRNAs(mi RNAs) in human tumorigenesis has been demonstrated by gene profiling and functional studies in hepatocellular carcinoma(HCC). Their aberrant expression revealed relations shared with other types of cancer,namely the up-regulation of miR-221/222. MiR-221/222 are two highly homologous microRNAs, whose upregulation has been obviously showed in HCC, which also has been considered to act as oncogenes. Here we will review the role of miR-221/222 in molecule and biomechanism,and explore the possibility of their use as new prognostic and therapeutic tools in HCC.

Key concepts: microRNA, Carcinogenesis, Hepatocellular carcinoma, Downregulation and upregulation, Cancer research, Gene, Gene expression profiling, Homologous chromosome

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