The Relationship between Platelet-activating Factor(PAF),Nitric Oxide Synthase(NOS) and Pulmonary Arterial Hypertension(PAH)

Objective To understand the relationship between platelet-activating factor,nitric oxide synthase and pulmonary hypertension.Methods 30 cases of patients with pulmonary hypertension caused by COPD(group A),20 cases of patients with primary pulmonary hypertension(group B),the COPD pulmonary artery pressure of 30 patients(group C),30 cases of healthy controls(Group D).PAF was detected by Double-antibody sandwich ELISA assay.Chemical colorimetric determination was used for serum NOS activity.Results The PAF and iNOS levels in group A and group B were significantly higher than in group C and D group.The cNOS levels in Group A and group B were significantly lower than that in group C and Group D,while group A was significantly higher than the B group.Correlation analysis showed that cNOS had significant negative correlation with group A and group B pulmonary artery pressure.Conclusion Conclusion: PAF may play a role in pulmonary hypertension.However,pulmonary artery pressure increase does not raise the level of PAF.The levels of cNOS and pulmonary artery pressure significantly have negative correlation.cNOS reduce the promotion of pulmonary hypertension and it has different inference in COPD lead to pulmonary hypertension and primary pulmonary hypertension.