Expression of E-cadherin and Beta-catenin in Endometrial Carcinoma

Objective:To detect the relationship between expression of E-cadherin and beta-catenin with endometrial carcinoma.Methods:A total of 65 specimens of endometrial carcinoma,38 normal endometrial tissues and 36 atypical hyperplasia endometrium tissues were evaluated by immunohistochemical technique with monocolonal antibodies against E-cadherin and beta-catenin.Results:The aberrant expression rates of E-cadherin and beta-catenin increased obviously from normal endometrial tissues,atypical hyperplasia endometrium tissues to endometrial carcinoma tissues(P 0.05).Expression of E-cadherin was positively correlated with tumor grade,mymetrial invasion,surgical stage and lymphnode matastasis(P0.05).Expression of beta-catenin was also significantly correlated with tumor grade,surgical stage and lymphnode matastasis(P0.05).Conclusions:The aberrant expression of E-cadherin and beta-catenin was positively related to oncogenesis,invasion,metastasis and prognosis of endomentrial carcinoma.It should be considered to a certain extent as an index of malignant degree and prognosis of endomentrial carcinoma.