Investigation of outcome of IVF-ET conducted in couples with different unexplained infertility

Ojective:To investigate the outcome of IVF-ET conducted in couples with different unexplained infertility.Methods:A total of 212 IVF-ET cycles with different unexplained infertility accepted short-time fertilization and were recruited to analyze retrospectively.Oocytes failed to extrude Pb2 were applied early rescue-ICSI in the cycles with low fertilization rate or completely failed fertilization after 6h sperms and oocytes incubation.IVF-ET outcomes of couples with primary(group A1,139cycles)or secondary(group A2,73cycles)unexplained infertility were compared.All cycles with MII oocytes were divided to IVF(groupB1,181 cycles)and rescue-ICSI group(group B2,26 cycles)to discuss.Results:1.Women in group A1 were younger,but with longer history of infertility,the IVF fertilization rate of MII oocytes and 2PN fertilization rate were lower compared with group A2.The rescue-ICSI cycle rate were higher obviously in group A1 than group A2(17.04% vs 4.17%,P0.05).The cancelation rate of cycles with no transferable embryos due to abnormal fertilization,failed to fertilization,and failed to cleavage or worse embryo quality in group A1 were higher than group A2(11.79%vs2.74%,P0.05).The implantation rate,clinical pregnancy rate and live birth rate per ET cycle had no differences in two groups.2.The fertilization rates in MII oocytes in group B1 were higher than B2(93.82% vs 84.78%,P0.05),but other indexes had no differences compared with each other.Conclusion:Couples with primary unexplained infertility had more chance with low fertilization rate or completely fertilization failure.They had the comparable IVF-ET outcomes compared with secondary unexplained infertility couples if combined short time fertilization with early rescue-ICSI.