2006•Zhongguo pu-wai jichu yu linchuang zazhiRequires access

Expression of CD44v6 in Gastric Carcinoma and Its Clinical Significance

Zhao Tin

Abstract

Objective To study the relationship between expression of CD44v6 in gastric carcinoma and neoplasm metastasis and prognosis. Methods Expression of CD44v6 in 52 cases of gastric carcinoma was assayed by flow immunocytometry, and its relation with clinical pathology and prognosis was analyzed. Results In 52 cases of gastric carcinoma tissue, the positive rate of CD44v6 expression was 67.31%(35/52); but the positive rate of CD44v6 expression in normal gastric tissue was 25.00% (13/52). The positive rate of expression was significantly different (P0.01). The positive rate of CD44v6 expression in gastric carcinoma tissues was related to the depth of carcinoma infiltration, lymph node metastasis and pTNM stage (P0.05). Conclusion Expression of CD44v6 plays an important role in invasion, metastasis and pTNM stage of gastric carcinoma. It may be used as a new indicator to predict metastatic potential and prognosis of gastric carcinoma.

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Key concepts: Gastric carcinoma, Medicine, Metastasis, Stage (stratigraphy), Carcinoma, Lymph node metastasis, Clinical significance, Infiltration (HVAC)