2008•International Journal of StomatologyRequires access

The role of stromal cell derived factor-1 and its receptor CXCR4 in the migration of adult stem cells

Ling Jun-q

Abstract

Stromal cell derived factor-1(SDF-1) is an important regulator of morphogenesis and chemiotaxis thatrelated to both hematopoietic and non-hematopoietic stem cells. It has been recently shown that SDF-1 binding toits receptor(CXCR4) is important in mediating the migration/homing of adult stem cells, therefore plays a pivotalrole in regeneration and reparation after tissue/organ injury. Research advances of SDF-1/CXCR4 axis in the migration of adult stem cells may provide a new way to study dental pulp stem cells(DPSC) migration, especially in the bone marrow-derived stem cells.

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Key concepts: Homing (biology), Stem cell, CXCR4, Stromal cell, Cell biology, Stem cell factor, Biology, Haematopoiesis