2002•Chinese Journal of Critical Care MedicineRequires access

Protective effect of atomolan on liver during ischemia-reperfusion injury

Wen Qin-shen

Abstract

Objective To explore the protective effect of atomolan in treating hepatic ischemia and reperfusion(I/R) injury.Methods Twenty rabbits were randomly divided into atomolan protection group and controlled group.Changes of several parameters,including alanine aminotransferase(ALT),aspartate aminotransferase(AST),xanthine oxidase(XO),malondiadehyde(MDA),glutathione peroxidase(GSH-PX) and superoxide dismutase(SOD) as well as liver morphological changes,and the effect of atomolan on them were observed during hepatic I/R injury.Results SOD and GSH-PX activity decreased significantly ( P 0 05),ALT, AST and XO activities as well as MDA concentration increased remarkably ( P 0 05),and abnormal morphological changes of hepatocytes were obvious during hepatic I/R injury;with treatment of atomolan,the abnormal changes of all above parameters were diminished remarkably ( P 0 05).Conclusion Atomolan possess preventive effects on hepatic I/R injury by eliminating oxygen free radicals(OFR).

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Key concepts: Xanthine oxidase, Superoxide dismutase, Medicine, Glutathione peroxidase, Alanine aminotransferase, Liver injury, Ischemia, Internal medicine