Correlation Between Serum Adiponectin,Leptin and Insulin Resistance in Gestational Diabetes Mellitus During Late Pregnancy

Objective To investigate the correlation between serum adiponectin(ADP),leptin(LEP) and insulin resistance(IR) in pregnant women with gestational diabetes mellitus(GDM) during late pregnancy.Methods A total of 166 pregnant women of 28-32 pregnant weeks were enrolled in the study.Serum insulin,ADP and LEP were determined in 84 patients with GDM(GDM group) and 82 pregnant women with normal glucose tolerance(NGT group).Homeostasis model assessment insulin resistance index,HOMA-IR,and insulin sensitivity index,ISOGTT,were calculated to assess the insulin resistance.Homeostasis β-cell function index(HBCI) and 30min net increment of insulin/30min net increment of glucose(ΔI30/ΔG30) were applied to evaluate the secretion function of islet β cells.Results The fasting insulin(FIns) level and HOMA-IR in the GDM group were markedly higher than those in the NGT group(P0.01 and P0.05 respectively),while ISOGTT,HBCI and ΔI30/ΔG30 in the GDM group were statistically lower than those in the NGT group(P0.01 or P0.05).The serum ADP level was significantly lower in the GDM group(P0.01),while the serum LEP level was higher(P0.01).A multiple linear stepwise regression analysis indicated that ADP and LEP were independent risk factors affecting GDM patients during late pregnancy.Conclusions Decreased serum adiponectin and increased serum leptin are closely correlated with insulin resistance in pregnant women with gestational diabetes mellitus(GDM) during late pregnancy.