EXPRESSION AND SIGNIFICANCE OF P21 AND P27 PROTEIN IN OVARIAN CARCINOMA

Objective To investigate the expressions and significance of P21 and P27 proteins in ovarian carcinoma. Methods The expressions of P21 and P27 protein in normal ovarian tissue(10 cases), benign ovarian tumor (10 cases) and ovarian carcinoma (30 cases) were analyzed by immunohistochemistry technique. Results The positive rates of P21 and P27 in normal ovarian and benign ovarian tumor groups were higher than that in ovarian carcinoma (P=0.014,0.004). The expression of P21 and P27 in carcinoma was associated with clinical stage (P=0.024,0.008), but not correlated with pathological type, histologic grade, ascites or lymphatic metastasis (P=0.067-0.562). Positive correlation was found between P21 and P27 expression in the three tissues (P=0.039). Conclusion The abnormal expression of P21 and P27 may directly affect cell cycle progression and tumorigenesis.Protein examination,especially combined examination of P21 and P27,has positive effects on prognosis and treatment of the cancer.