Recovery Effects of Rat's Intestinal RNA on Post-abdominal-γ-irradiation Intestinal Mucosal Damages

Objective To explore the recovery effects of intestinal RNA on post-abdominal-γ-irradiation damages in intestinal mucosa in mice.Methods A total of 36 BALB/c male mice were randomly divided into three groups,including the normal control group,the simple irradiation group,and the additional intestinal RNA administration group(n=12,each).The mice received abdominal irradiation with 11.5 Gy60Co γ-ray,within 1～3h after irradiation they were received intestinal RNA from normal rats injection into jejunum.Eighteen-hour after irradiation,the mice were dissected for determining crypt survival rate,the morphological changes of intestinal mucosa were observed and analyzed under TEM and SEM.Results Compared with the normal control group,the crypt survival rate of simple irradiation group decreased significantly(P0.01).Compared with the simple irradiation group,intestinal RNA administration significantly increased the jejununal crypt survival rate(P0.01).In addition,it further improved the intestinal mucosal morphology and reduced injury of intestinal villie.Conclusion Rat's intestinal RNA possesses evident reparation effects on the radiation injured intestinal mucosa.