Repair of rat spinal cord injury by vein transplantation of olfactory ensheathing cells

[Objective]To investigate the effect and possibility of spinal cord injury repaired by transplantation of olfactory ensheathing cells(OECs).[Method]Wistar rats with T10 spinal cord hemisection were divided into 4 groups:(1)Injured site transplantation group,(2)vein transplantation group,(3)D/F12 transplantation group,(4)control group.The functional recovery of spinal cord injury was observed with CBS scores at regular time.The tissue sections of each group were abtained at 5 weeks and 10 weeks postoperatively to observe the axon regeneration and the survival of olfactory ensheathing cells.[Result]The experiment showed that rat transplanted with OECs throuth injured site and vein had more improvement than the two control groups.The effect between groups A and B had no significant difference.[Conclusion]The method of treating rat spinal cord injury by transplanting OECs via the vein is simple,and avoids various complications.It is recommended that the method should be widely used in the clinical practice.