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Topical application of bFGF in the regeneration of the peripheral nerve after electrical injury

Xue Li

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Abstract

AIM: To study the effects of bGFG on promoting nerve regeneration by injecting bFGF to the surrounding areas of the sciatic nerve injured by electric current. METHODS: 24 rabbits were divided randomly into the experiment group and the control group, which were sub divided into 2 week, 1 month and 3 month groups. Then the sciatic nerve was injured by 60 Hz 125 V alternating current. The injury time was 3 seconds. 500 AU/d bFGF was injected to the surrounding areas of the sciatic nerve. The control group was injected with normal saline. RESULTS: The conduction velocity and muscle tension in experiment group increased more obviously than those in the control group. The ultrastructure of nerve fibers changed slightly in the experiment group. The structure of the regenerative fiber was more mature than that of the control group. CONCLUSION: Local application of bFGF can significantly enhance the injured nerve regeneration.

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What this paper is about

AIM: To study the effects of bGFG on promoting nerve regeneration by injecting bFGF to the surrounding areas of the sciatic nerve injured by electric current. METHODS: 24 rabbits were divided randomly into the experiment group and the control group, which were sub divided into 2 week, 1 month and 3 month groups. Then the sciatic nerve was injured by 60 Hz 125 V alternating current. The injury time was 3 seconds. 500 AU/d bFGF was injected to the surrounding areas of the sciatic nerve. The control group was injected with normal saline. RESULTS: The conduction velocity and muscle tension in experiment group increased more obviously than those in the control group. The ultrastructure of nerve fibers changed slightly in the experiment group. The structure of the regenerative fiber was more mature than that of the control group. CONCLUSION: Local application of bFGF can significantly enhance the injured nerve regeneration.

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Available abstract

AIM: To study the effects of bGFG on promoting nerve regeneration by injecting bFGF to the surrounding areas of the sciatic nerve injured by electric current. METHODS: 24 rabbits were divided randomly into the experiment group and the control group, which were sub divided into 2 week, 1 month and 3 month groups. Then the sciatic nerve was injured by 60 Hz 125 V alternating current. The injury time was 3 seconds. 500 AU/d bFGF was injected to the surrounding areas of the sciatic nerve. The control group was injected with normal saline. RESULTS: The conduction velocity and muscle tension in experiment group increased more obviously than those in the control group. The ultrastructure of nerve fibers changed slightly in the experiment group. The structure of the regenerative fiber was more mature than that of the control group. CONCLUSION: Local application of bFGF can significantly enhance the injured nerve regeneration.

Key concepts: Sciatic nerve, Regeneration (biology), Medicine, Nerve conduction velocity, Saline, Peripheral nerve, Sciatic nerve injury, Nerve injury

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Topical application of bFGF in the regeneration of the peripheral nerve after electrical injury — Research Paper | ScholarLens