Study on Lipopge1 in Treatment of Diabetic Nephropathy

Objective To observe the effectiveness of lipoPGE1 in treatment of diabetic nephropathy and the mechanism of the renal protection of the drug.Methods One hundred and twenty patients with diabetic nephropathy due to type 2 diabetes mellitus were randomly divided into 2 groups,60 in Treatment Group,and 60 as controls.LipoPGE1 was used intravenously in the Treatment Group for 4 weeks while routine management of diabetes such as food intake control,physical exercises and oral drugs or injection of insulin was conducted in both of the 2 groups.Urinary albumin of 24 hours,serum urea nitrogen and creatinine were employed for evaluation as well as the side-effects.Results By the end of the trial,urinary albumin,urinary albumin of 24 hours,serum urea nitrogen and creatinine were decreased significantly compared with those before intravenous lipoPGE1 treatment or with those in the controlled group(P0.05).Conclusion Urinary albumin and urinary albumin of 24 hours were decreased significantly after intravenous lipoPEG1 treatment.Therefore,it is a safe and effective drug in the treatment of diabetic nephropathy.