2002•Unpublished venueRequires access

Effects of Nerve Growth Factor on Neuron Apoptosis after Spinal Cord Injury in Rats

Xiaojian Cao

Abstract

Objective: To explore the effects of nerve growth factor(NGF) on neur onal apoptosis and the protective mechanisms of injured spinal cord (ISC). Metho ds: The spinal cord injury(SCI) of Wistar rats was done by Allen′s weight dropp ing way by a 10 g×2.5 cm impact on the posteriors of spinal cord T8. NGF(20 μ1 /60 μg) or normal saline was given to treatment group rats through catheter int o subarachnoid space at 0?2?4?8?12?24 h after SCI. Apoptotic neurons were d etected by TUNEL stain. Results:There was no apoptotic neurons in spinal cord o f normal rat group. The apoptotic neurons was found 2 h after SCI in NGF treatme nt group and significantly less than normal saline treatment group(P 0.01).Conc lusion:NGF may protect ISC by suppressing the neuronal apoptosis after SCI.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Nerve growth factor, Spinal cord injury, Spinal cord, TUNEL assay, Apoptosis, Medicine, Saline, Anesthesia