Application of midazolam combined with propofol or fentanyl to colonoscopy

Objective:To making colonoscopy more smooth; to compare the efficacy of two kinds of methods,make sedation and anesthesia have the ahemative for easy colonoscopy. Methods:Three hundred and two cases were included in this study, the patients were randomized into three groups-MF group ( midazolam and fentanyl group n = 90), MP group ( midazolam and propofol group n = 162), contrast group ( no sedative was employed prior to intubation n =50 ). MF group with midazolam 1～2 mg iv plus fentanyl 50 mg im before the procedure, MP group with midazolam 1～1.5 mg iv plus propofol 0. 5 ～2.0 mg/kg iv) (Range 25～145 mg). Heart rate, blood pressure and SPO 2 were obtained for each patient before the procedure and monitored continuously during and after tile procedure. Results:Data in MF group and MP group showed high satisfaction with sedation and anesthesia, specially in MP group (P0.001). Amnesia in MP groups were significant different from MF group. There were significant change of pulse and blood pressure in MP (P0.001). Clinical impotant changes in blood pressure were most frequently noted.Conclusions:Both of the two methods can produce safe and effective sedation and anesthesia for colonoscopy. Midazolam combine fentanyl appears to decrease the risk of cardiac complications, yet midazolam combine propofol appears more effective in seriously nervous patients.