The clinical effect of irbesartan on hypertension assessed by ambulatory blood pressure monitoring

OBJECTIVE To investigate the clinical effect and safety of irbesartan on essential mild to moderate hypertension.METHODS Forty patients with essential mild to moderate hypertension were enrolled and arranged randomly to two groups.They were treated with irbesartan or benazepril respectively for 4 weeks and visited every two weeks.24-hour ambulatory blood pressure monitoring(ABPM) was performed before and after drug administration.RESULTS The total efficacy rate of irbesartan was(85.0%).The night systolic and diastolic blood pressure were reduced significantly observed in ABPM(P(0.01)),which were better than benazepril(P(0.05)).Blood pressure rhythm and heart rate were uninfluenced.No obvious adverse reaction occurred.CONCLUSION the antihypertensive effect of irbesartan is remarkable and steady.The safety is also good.