ScholarLens Back to search
2013•Chinese Journal of Aesthetic MedicineRequires access

Effects of simvastatin on osteoblast activity of human dental pulp stem cells

Yun Hui-yuan

Open publisher page 0 citations

Abstract

Objective To study the effect of simvastatin on osteoblast activity of human dental pulp stem cells(DPSCs).Methods DPSCs were in vitro cultured.Cells were inoculated in different concentrations of simvastatin.Alkaline phosphatase(ALP)activity and the expression of Bone sialoprotein(BSP) were measured.Results Compared with control group,osteoblast activity of human DPSCs were more significant in experiment groups with different concentrations of simvastatin(10-6mol/L、1×10-7mol/L、1×10-8mol/L() P0.05).The maximum effect on the activity was observed at the concentration of 1 ×10-7mol/L.Conclusion Optimal concentration of simvastatin can improve the osteoblast activity of human DPSCs.

About this research paper

What this paper is about

Objective To study the effect of simvastatin on osteoblast activity of human dental pulp stem cells(DPSCs).Methods DPSCs were in vitro cultured.Cells were inoculated in different concentrations of simvastatin.Alkaline phosphatase(ALP)activity and the expression of Bone sialoprotein(BSP) were measured.Results Compared with control group,osteoblast activity of human DPSCs were more significant in experiment groups with different concentrations of simvastatin(10-6mol/L、1×10-7mol/L、1×10-8mol/L() P0.05).The maximum effect on the activity was observed at the concentration of 1 ×10-7mol/L.Conclusion Optimal concentration of simvastatin can improve the osteoblast activity of human DPSCs.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect of simvastatin on osteoblast activity of human dental pulp stem cells(DPSCs).Methods DPSCs were in vitro cultured.Cells were inoculated in different concentrations of simvastatin.Alkaline phosphatase(ALP)activity and the expression of Bone sialoprotein(BSP) were measured.Results Compared with control group,osteoblast activity of human DPSCs were more significant in experiment groups with different concentrations of simvastatin(10-6mol/L、1×10-7mol/L、1×10-8mol/L() P0.05).The maximum effect on the activity was observed at the concentration of 1 ×10-7mol/L.Conclusion Optimal concentration of simvastatin can improve the osteoblast activity of human DPSCs.

Key concepts: Simvastatin, Dental pulp stem cells, Osteoblast, Alkaline phosphatase, Bone sialoprotein, Chemistry, Cell biology, In vitro

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of simvastatin on osteoblast activity of human dental pulp stem cells — Research Paper | ScholarLens