The effect of intensive statin pretreatment on stable coronary atherosclerotic heart disease patients treated withpercutaneous coronary intervention

Objective To study the effect o f intensive statin pretreatment on stable coronary atherosclerotic heart disease patients treated with percutaneous coronary inte rvention(PCI),and probe into them echanisms.Methods:78 patients with stable coronary atherosclerotic heart disease were randomized to receive atorvastatin(20mg /d,standard statin group)or(60-80mg /d,intensive statin group)after admition.TIMI grade flow(TGF),corrected TIMI frame count(CTFC)and TIMI myocardial perfusion grade(TMPG)of the intervened vessel were recorded before and after PCI.Creatin kinase isoenzyme MB(CK-MB),troponin T and plasma level of high sensitivity C-reactive protein(hs-CRP)and serum creatinine(SCr)were measured before and 24 hours after the procedure.Results: The TFG 、CTFC and TMPG after stent deployment was significantly improved in intensive statin group than those in standard statin group(P0.05).Patients with no reflow phenomenon were less in intensive statin group(P0.01).Twenty-four hours after the procedure,CK-MB,TnT and hs-CRP were significantly lower in intensive statin group.The level of SCr was no difference between two groups.Conclusions:Intensive statin pretreatment before PCI can further improve myocardial blood perfusion,protect myocardium from ischemic injury.This benefitis associated with the lowering of hs-CRP,TnT.