Effect of Statin Therapy Before Percutaneous Coronary Intervention on Periprocedural Myocardial Injury

Objective:To study the effect of statin in reduction of myocardial injury in patients undergoing percutaneous coronary intervention(PCI).Methods:Total of 137 patients undergoing PCI were included,66 received statins before PCI,while 71 were not given statins at the time of PCI. Creatine kinase-MB and troponin I were measured at baseline and at 8 and 24 hours after the procedure.Results:Postprocedural peak levels of troponin I (0.15±0.23) versus (0.48±1.08)ng·mL-1,P0.05,and creatine kinase-MB (2.44±3.05) versus (4.98±10.89) ng·mL-1,P0.05 were lower in the statin than in the control group. Detection of markers of myocardial injury above the upper normal limit was significantly lower in the statin group versus the control group:24% versus 48% for troponin I (P0.05),10% versus 20% for creatine kinase-MB (P0.05). Myocardial infarction by troponin I determination was detected after procedure in 12% of patients in the statin group and in 25% of those in the control group (P0.05).Conclusion:Pretreatment with statin for 7 days significantly reduces procedural myocardial injury in elective PCI.