Determination of chlorzoxazone and paracetamol in lunan-beite tablet by the new vierordt spectrophotometry

ObjectiveTo determine the contents of chlorzoxazone and paracetamol in Lunan-beite tablet using a new Vierordt method. MethodsThe new Vierordt spectrophotometry was applied for the direct determination of chlorzoxazone and paracetamol in Lunan-beite tablet without any preliminary separation. The detection wavelengths were set at 243.9 nm(λ 1 ) and 257.6 nm(λ 2).ResultsThe linear range of chlorzoxazone measured was over ( 8.47～ 42.36)μg/ml (r= 0.9990), The linear range of paracetamol measured was over ( 8.83～ 44.16)μg/ml (r= 0.9994). The recoveries and relative standard deviations of chlorzoxazone and paracetamol were 100.1 %, 0.89 % and 100.6 %, 0.44 %, respectively.ConclusionThe method was simple, rapid and reproducible, the interference of two componets on each other may be eliminated and the results were satisfactory.