MMP_2 ,MMP_9 expressions and their tissue inhibitors TIMP_1, TIMP_2 in lung carcinoma and their clinical significance

Objective To investigate the expressions of MMP2 ,MMP9 and their tissue inhibitors TEMP1 , TIMP2 in lung carcinoma and their clinical significance. Methods Immunohistochemistry (S-P method) was used to detect the expressions of MMP2, MMP9 and TIMP1, TIMP2 in 58 cases of lung carcinoma and 58 subjects with normal lung tissues.Results The expressions of MMP2,MMP9,TIMP, ,TIMP2 were 63.8% ,56.9% ,55.2% ,and 55.2% respectively.There were remarkable differences in expression between of lung carcinoma and normal lung tissue, and the expressions of MMP2, MMP9, TIMP1 , TIMP2 were closely correlated to lymph node metastasis and clinical stages.Conclusion The expressions of MMP2 ,MMP9 ,TMP1 ,TIMP2 are closely correlated to lymph node metastasis and clinical stage of lung carcinoma, and may serve as parameters for determining tumor invasive and metastatic biologic behavior.