Concomitant three Dimensional Conformal Radiotherapy Plus Chemotherapy for Advanced Esophageal Carcinoma

Objective To evaluate the response and acute toxicity of three dimensional conformal radiotherapy (3DCRT) plus chemotherapy for advanced esophageal carcinoma. Methods 20 patients with advanced esophageal carcinoma were treated with three dimensional conformal radiotherapy combined with chemotherapy DF(DDP and 5-FU), Results All patients completed treating schedule.Grade 1-2 acute radiation esoph-agitis occurred in 80%(16/20) and grade 3 in 35%(7/20) patients: Grade 1-2 acute radiation bronchitis occurred in 20%(4/20) and grade 3 in 5%(1/20) patients; Acute bone marrow suppression occurred in 95%(19/20) and grade 3-4 in 65% (13/20)patients. The overall response rate was 100%, with complete response (CR) 80% (16/20) and partial response (PR) 20% (4/20),the 1-and 2-year survival rates were 65% (13/20), 35%(7/20).Conclusion Three dimensional conformal radiotherapy (3DCRT) plus chemotherapy can be considered effective advanced esophageal carcinoma. With fewer acute complications. Complications and long-term survival require further study.