Research Progress of Matrix Metalloproteinases and Their Inhibitors in Hypertension

Absrtact:Matrix metalloproteinases are a family of Zn2 +dependent protein hydrolysis enzyme,are mainly responsible for the degradation of extracellular matrix and tissue remodeling,can degrade extracellular matrix,and play an important role in various physiological processes such as embryonic development,tissue remodeling,inflammation control,tumor disease,and so on.Now the mechanism of action in the occurrence and development of hypertension and target organ damage,clinical significance and treatment progress is elaborated in this paper.