2008•Connective Tissue ResearchRequires access
Dysregulation of Matrix Metalloproteinases and their Tissue Inhibitors by S100A4
Renate Elenjord, Hilde Ljones, Elisabeth Sundkvist, Thrina Loennechen, Jan Winberg
Open publisher page 17 citations
Abstract
The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer. This mini review focuses on in vitro and in vivo studies indicating S100A4 involvement in regulation of MMPs and TIMPs, and the biological and pathobiological consequences of this regulation.