The analgesic efficacy of preoperative versus postoperative parecoxib in gynecologic surgery

Objective To compare the analgesic efficacy of preoperative or postoperative parecoxib administration in gynecologic surgery.MethodsSixty patients scheduled for gynecologic surgery were randomized into two groups.Group A:parecoxib 40 mg were intravenous 10 min before anesthesia and 12 hours postoperation.Group B:parecoxib 40 mg were intravenous at end of operation and 12 hours postoperation.Patients-control analgesia(PCA)with intravenous fentanyl.were used in both groups.Visual analog scale(VAS)score and Bruggman comfort scale(BCS)score were recorded at 2,4,6,12 and 24 h after operation.The PCA by patients were recorded in both groups.ResultsThe times of PCA by patients were significantly higher in B group than in A group.The VAS scores and BCS scores at the 2,4,6 and 12 h not 24 h after operation were significantly lower in A group than in B group.There were no serious adverse effects in both groups.ConclusionIntravenous parecoxib before surgery has better analgesic effect than administered postoperative in gynecologic surgery.