Effect of large doses of ademetionine on hyperbilirubinemia caused by severe chronic liver disease

Objective To observe the effects of high dose ademetionine on hyperbilirubinemia caused by all kinds of causes.Methods 63 cases of severe chronic liver disease(39 cases of viral hepatitis induced liver cirrhosis,18 cases of alcoholic cirrhosis,2 cases of drug induced liver disease,4 cases of primary biliary cirrhosis).At the time of admission,the mean serum bilirubin level was 195.1 mmol/L,and the liver function had no significant improvement after 4 weeks of regular treatment while the bilirubin level was improved.The dose of ademetionine increased to 2.0 g iv.(twice daily) with the basis of original treatment.The liver function was observed weekly with the total serum bilirubin level as the main indicator.Results 3 cases of cirrhosis induced by hepatitis B and alcohol factors dropped out due to massive upper gastrointestinal hemorrhage for less than 2 weeks of treatment.60 cases were treated for 4 weeks,and the total serum bilirubin level decreased,compared with regular treatment(P0.01).Conclusion Large dose of ademetionine can be attempted in treatment for hyperbilirubinemia induced by some severe liver disease when the effects of conventional treatment is poor.