Effect of Needling Taixi(KI3)Acupoint and Sham Point on Functional Magnetic Resonance Imaging in Mild Cognitive Impairment Patients

Objective:To observe the effect of needling Taixi(KI3) and sham point on the activation of various encephalic region in patients with mild cognitive impairment(MCI)by functional magnetic resonance imaging(fMRI) technique.Methods:Twenty-four patients with MCI were randomly divided into KI3 group and sham point group.The patients received needling right lateral Taixi(KI3) or sham point according to the experimental method.We applied a block design,which included three blocks,resting state,rotating state and needle-withdrawing state.Scanned images were analyzed by SPM2.Results:Right cingulate gyrus(BA24),bilateral medial frontal gyrus(BA6),and left postcentral gyrus(BA3)were evoked after needling Taixi(KI3).Left postcentral gyrus(BA2),left inferior parietal lobule(BA40),and left cerebellum were evoked after needling sham point.Conclusion:Compared with needling sham point,needling Taixi(KI3) can activate the target-based encephalic region of MCI patients,and has integral adjustment on related encephalic region.