Effect of rosiglitazone on serum MMP-2 and TIMP-1 in diabetic hypertension

Objective To observe the effect of rosiglitazone on MMP-2 and TIMP-1 in the patients with diabetic hypertension.Methods 40 diabetic patients with essential hypertension(DMEH)were divided into 2 groups:(1)group A(n=20)without rosiglitazone treatment;(2)group B(n=20)undergoing rosiglitazone treatment.ELISA method was adopted to determine the levels of MMP-2 and TIMP-1,and the differences in MMP-2 and TIMP-1 between pre-and post-use of rosiglitazone were observed.Results At 16 weeks of the treatment by rosiglitazone,the level of MMP-2 was higher after treatment than before treatment [(37.9±3.9)vs(27.5±4.3)μg/L,P0.05],and the level of TIMP-1 was lower after treatment than before treatment[(410±81)vs(468±101)μg/L,P0.01].Conclusions Rosiglitazone not only improves blood sugar and blood pressure,but also raises the level of MMP-2 and reduces the level of TIMP-1.