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Protective Effect of Shenfu Injection with Antioxidant System on Rats' Kidney after the Ischemia-reperfusion Injury

Zhang Tingmo

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Abstract

Objective To explore the protective effect of Shenfu injection combined with antioxidant system on rats' kidney after ischemia-reperfusion injury.Methods Twenty-one male Sprague Dawley(SD) rats were randomly divided into 3 groups: sham operation group(sham group),ischemia-reperfusion group(IR group),and shenfu injection treated group(SF group).The rats were anesthetized with valebarbitone.Bilateral kidneys were exposed through midline incision.The right kidney underwent the nephrectomy and left renal pedicels were occluded for 60 minutes with a traumatic mini-clamp and then unclamped for 24 hours.Animals in SF group received Shenfu injection(10 ml/kg) through intraperitoneal injection every day for 7 days.About 24 hours after reperfusion,superoxide dismutase(SOD),CAT and malonical aldehyde(MDA) were measured.Results The levels of MDA were lower in SF group than those in IR group(P0.05).The level of SOD and CAT in SF group increased more significantly than which did in IR group(P0.05).Conclusion Our finding suggests that antioxidant system in SF group works more efficiently than IR group to overcome oxidative stress in renal ischemia-reperfusion injury.

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Objective To explore the protective effect of Shenfu injection combined with antioxidant system on rats' kidney after ischemia-reperfusion injury.Methods Twenty-one male Sprague Dawley(SD) rats were randomly divided into 3 groups: sham operation group(sham group),ischemia-reperfusion group(IR group),and shenfu injection treated group(SF group).The rats were anesthetized with valebarbitone.Bilateral kidneys were exposed through midline incision.The right kidney underwent the nephrectomy and left renal pedicels were occluded for 60 minutes with a traumatic mini-clamp and then unclamped for 24 hours.Animals in SF group received Shenfu injection(10 ml/kg) through intraperitoneal injection every day for 7 days.About 24 hours after reperfusion,superoxide dismutase(SOD),CAT and malonical aldehyde(MDA) were measured.Results The levels of MDA were lower in SF group than those in IR group(P0.05).The level of SOD and CAT in SF group increased more significantly than which did in IR group(P0.05).Conclusion Our finding suggests that antioxidant system in SF group works more efficiently than IR group to overcome oxidative stress in renal ischemia-reperfusion injury.

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Available abstract

Objective To explore the protective effect of Shenfu injection combined with antioxidant system on rats' kidney after ischemia-reperfusion injury.Methods Twenty-one male Sprague Dawley(SD) rats were randomly divided into 3 groups: sham operation group(sham group),ischemia-reperfusion group(IR group),and shenfu injection treated group(SF group).The rats were anesthetized with valebarbitone.Bilateral kidneys were exposed through midline incision.The right kidney underwent the nephrectomy and left renal pedicels were occluded for 60 minutes with a traumatic mini-clamp and then unclamped for 24 hours.Animals in SF group received Shenfu injection(10 ml/kg) through intraperitoneal injection every day for 7 days.About 24 hours after reperfusion,superoxide dismutase(SOD),CAT and malonical aldehyde(MDA) were measured.Results The levels of MDA were lower in SF group than those in IR group(P0.05).The level of SOD and CAT in SF group increased more significantly than which did in IR group(P0.05).Conclusion Our finding suggests that antioxidant system in SF group works more efficiently than IR group to overcome oxidative stress in renal ischemia-reperfusion injury.

Key concepts: Medicine, Superoxide dismutase, Ischemia, Anesthesia, Nephrectomy, Kidney, Oxidative stress, Intraperitoneal injection

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Protective Effect of Shenfu Injection with Antioxidant System on Rats' Kidney after the Ischemia-reperfusion Injury — Research Paper | ScholarLens