Comparison of hematologic recovery between autologous peripheral blood stem cell plus bone marrow transplants and simple autologous bone marrow transplant

Objective[WT5BZ]:To compare the speeds of engraftment and concerning clinical data between autologous peripheral blood stem cell plus bone marrow transplants (APBSCT+ABMT)and simple autologous bone marrow transplant(ABMT).[WT5HZ]Methods:[WT5BZ]APBSCT+ABMT( n =10) and ABMT( n =10) were used on the treatment of acute leukemia and lymphoma patients,their data were studied.[WT5HZ]Results:[WT5BZ]The average days reach WBC1.0×10 9·L 1 ,N0.5×10 9·L 1 and Plt50×10 9·L 1 were 10,10.5,12.5 in APBSCT+ABMT group and 15,17,24 in ABMT group respectively( P 0.05).There was a significant decrease in the number of plasma and platelets transfusions in the APBSCT+ABMT group as compared with ABMT group( P 0.01).The rate of Tienam use was significantly greater in ABMT group than in APBSCT+ABMT group( P 0.05, P 0.01).There was a significant difference about the rate and degree of bleeding between these two groups ( P 0.05),and also a significant shorting of living in laminar air flow bioclean room in APBSCT+ABMT group than in ABMT group ( P 0.01).No difference was seen between two groups about reducing of hemoglobin and the number of red blood cells transfusion( P 0.05).[WT5HZ]Conclusion:[WT5BZ]APBSCT+ABMT can improve the rate of hematologic recovery,and thus,decrease the rate of infection,bleeding,transfusion,antibiotics usage and length of hospitalization,it is an effective therapy for malignancies.