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Expressions and significance of S100A4,MMP-2 in bladder transitional cell tissue

XU Zhong-hua

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Abstract

Objective To study the expression of S100A4 and matrix metalloproteinase-2(MMP-2) in bladder transitional cell carcinoma(TCCB) tissues and its relationship with tumor invasion and metastasis.Method The S100A4 and MMP-2 were detected by immunohistochemical method in TCCB.Results The positive rate of S100A4 and MMP-2 in TCCB of were 60% and 55% respectively,while no expression or micro-expression in normal tissue. The expression of S100A4 and MMP-2 in TCCB was relative to infiltrating depth and grade(P0.01),S100A4 and MMP-2 expression was relative in TCCB(r=0.66,P0.01).Conclusions The expression S100A4 and MMP-2 in TCCB is raised,its over-expression is associated with the invasion and metastasis of TCCB.

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Objective To study the expression of S100A4 and matrix metalloproteinase-2(MMP-2) in bladder transitional cell carcinoma(TCCB) tissues and its relationship with tumor invasion and metastasis.Method The S100A4 and MMP-2 were detected by immunohistochemical method in TCCB.Results The positive rate of S100A4 and MMP-2 in TCCB of were 60% and 55% respectively,while no expression or micro-expression in normal tissue. The expression of S100A4 and MMP-2 in TCCB was relative to infiltrating depth and grade(P0.01),S100A4 and MMP-2 expression was relative in TCCB(r=0.66,P0.01).Conclusions The expression S100A4 and MMP-2 in TCCB is raised,its over-expression is associated with the invasion and metastasis of TCCB.

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Available abstract

Objective To study the expression of S100A4 and matrix metalloproteinase-2(MMP-2) in bladder transitional cell carcinoma(TCCB) tissues and its relationship with tumor invasion and metastasis.Method The S100A4 and MMP-2 were detected by immunohistochemical method in TCCB.Results The positive rate of S100A4 and MMP-2 in TCCB of were 60% and 55% respectively,while no expression or micro-expression in normal tissue. The expression of S100A4 and MMP-2 in TCCB was relative to infiltrating depth and grade(P0.01),S100A4 and MMP-2 expression was relative in TCCB(r=0.66,P0.01).Conclusions The expression S100A4 and MMP-2 in TCCB is raised,its over-expression is associated with the invasion and metastasis of TCCB.

Key concepts: Matrix metalloproteinase, Immunohistochemistry, Transitional cell carcinoma, Pathology, Transitional Cell, Metastasis, Matrix (chemical analysis), Biology

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