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2003•Chongqing Yike Daxue xuebaoRequires access

Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder

Peng Dongtao

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Abstract

Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.

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What this paper is about

Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.

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Available abstract

Objective:To study the expression and clinical significance of matrix metalloproteinase(MMP9,MMP2)in transitional cell carcinoma of bladder(TCCB).Methods:Applying S-P immunohistochemical technique,expression of MMP9 and MMP2 was studied in 64 TCCB.Results:There was 60.93%(39/64) with MMP9 and 42.19%(27/64) with MMP2 expression.There was a significant correlation between MMP9 expression and PCNA,pathological grade,clinical stage,tumor size.However,the relationship had not been found with patient age,sex as well as the number of tumor.Conclusion:MMP9 appears to be an independent biological marker for predicting prognosis and comprehensive treatment of TCCB.

Key concepts: MMP2, MMP9, Proliferating cell nuclear antigen, Pathological, Immunohistochemistry, Transitional cell carcinoma, Matrix metalloproteinase, Clinical significance

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Expression significance of MMP9,MMP2 and PCNA in transitional cell carcinoma of bladder — Research Paper | ScholarLens