Clinical distribution and antibiotic resistance of Acinetobacter baumannii in lower respiratory infections

Objective To investigate the clinical distribution and antibiotic resistance of Acinetobacter baumannii in lower respiratory infections for the rational use of antimicrobial agents.Methods Using disk diffusion method(K-B)for drug susceptibility testing,and drug sensitivity test to antibiotics in 169 strains of Acinetobacter baumannii was analyzed retrospectively.Results A total of 169 strains of Acinetobacter banmannii were mainly isolated from ICU(36.1%),department of neurosurgery(25.4%).Acinetobacter baumanii had the highest susceptibility to meropenem,the resistant rate was 7.1%,followed by imipenem(9.5%),cefoperazone/sulbactam(14.8%)piperacillin/tazobactam(16.6%),which had higher degree of drug resistance rates to the other antibaeterials,and had higher multidrug-resistantce.Conclusion Acinetobacter baumannii strains are mainly isolated from ICU and department of neurosurgery.Carbapenems are still the most active agent against Acinetobacter baumannii,followed by β-lactam / β-lactamase inhibitors.Therapy should be decided according to the results of susceptibility testing.It is very important to select rational drugs correctly according to the results of antibiotics susceptibility tests for controlling the infection effectually and delaying the occurrence of bacteria resistance.