Drug resistance of Acinetobacter baumannii and its clinical significance

OBJECTIVE To investigate the present situation of Acinetobacter baumannii infections and explore the drug resistance to the commonly used antibiotics so as to provide basis for reasonable use of antibiotics.METHODS The clinical specimens obtained from the hospitalized patients between Jun 2011and Jun 2012were cultured for pathogens,then identification and the drug susceptibility testing were performed by using VITEK2Compact fully automatic microorganism analyzer.RESULTS A total of 158strains of A.baumannii were isolated from the clinical specimens,among which 76.58% were isolated from respiratory tract secretions,followed by wound secretions(13.29%).Of all the A.baumannii isolated,27.85% were isolated from the surgical ICU,14.56%from the cadres department,and 10.76% from the respiratory internal medicine department.The A.baumannii strains have produced high drug resistance to the commonly used antibiotics;except for 31.6% to cefoperazone-sulbactam,the drug resistance of the A.baumannii strains varied between 53.8% and 90.5%.Totally 89strains of pandrug-resistant A.baumannii were isolated from the 158strains of A.baumannii,accounting for 56.33%,the drug susceptibility rate to polymyxin E was up to 100.0%,and the drug resistance rate to cefoperazone-sulbactam was 53.6%.CONCLUSIONThe A.baumannii is highly resistant to the commonly used antibiotics,it is necessary to use antibiotics based on the result of drug susceptibility testing.The polymyxin and cefoperazone-sulbactam or sulbactam-containing drugs are preferred for the treatment of pandrug-resistant A.baumannii infections.