Value of combined detection of three indexes to the differential diagnosis of lung squamous cell cancer and adenocarcinoma

Objective To investigate the combined detection of novel aspartie proteinase A(Napsin A),thyroid transcription factor-1(TTF-1) and P63 protein to the differential diagnosis of lung squamous cell cancer and adenocarcinoma.Methods The immunohistochemistry EnVision two-step detection was used to detect the expressions of Napsin A,TTF-1 and P63 protein in 178 patients with lung cancer.Results The total positive rates of Napsin A,TTF-1 and P63 protein in lung cancer tissue were 44.94%,53.93% and 40.44%,which showed significant differences(P0.05).The positive rates of Napsin A and TTF-1 were significantly higher in lung adenocarcinoma tissue(81.25% and 79.17%) than those in lung squamous cell tissue(0)(P0.01).The positive rate of P63 was significantly lower in lung adenocarcinoma tissue(10.41%) than that in lung squamous cell tissue(96.20%)(P0.01).The sensitivity and specificity of Napsin A to lung adenocarcinoma were higher than those of TTF-1,but there was no significant difference(P0.05).Conclusion The combined detection of Napsin A,TTF-1 and P63 has a great value to the differential diagnosis of lung squamous cell cancer and adenocarcinoma.