2010•China Occupational MedicineRequires access
Effects of sulfur dioxide on the immediate asthma reaction in rats
Zheng Ren-sheng
Open publisher page 1 citations
Abstract
Objective To investigate the effects of different concentrations of sulfur dioxide(SO2) on the immediate asthma reaction in rats.Methods 40 Wistar rats were randomly divided into 4 groups,a control group(group A),an asthma model group(Group B),a low SO2 concentration group(group C,15 mg/m3) and a high SO2 concentration group(group D,30 mg/m3).The rats were executed one week after the exposure ended,and the changes of airway resistance in each rat was evaluated for 30 min.The pathological changes of lungs were observed.The levels of IgE and interleukin-13(IL-13) of the serum were detected by ELISA.Results ①The airway resistance:group B was higher than that of group A(P0.01),group C and D were higher than that of group B(P0.01).②The expression of IL-13:group B was gradually higher than that of group A(P0.01),while no significant differences were found among group C,D and group B(P0.05).The concentration of IgE in group B was higher than that of group A(P0.05),but no significant differences were observed among group B and group C,D(P0.05).③The pathological changes of lung showed the epithelial shedding,infiltration of inflammatory cells in peribronchial and partly fibrosis on the basement membrane.Conclusion SO2 exposure may exacerbate immediate asthma reaction in rats.