Prospective study on the effect of budesonide inhalation suspension given by step nebulising ihalation for infant asthma.

Objective To investigate the clinical effects of budesonide inhalation suspension step-nebulising inhalation therapy for infant asthma.Methods Totally 112 children with moderate or serious infant asthma from Dec 2004 to Dec 2005 were divided into two groups randomly.The budesonide inhalation suspension group(48 cases)(nebulising group) was given budesonide inhalation suspension through jet nebulizer;pulmicort aerosol group(64 cases)(aerosol group) was given pulmicort aerosol through meterd dose inhalers(MID) + spacer inhaler.The inhalation dosage of glucocorticosteroid decreased greatly according to the day-time and night-time clinical symptom score.The day-time and night-time clinical symptom score、compliance、attack times and inhalation dosage of glucocorticosteroid during remissive period were compared at every clinical visit or by telephone.All patients were followed up for 48 weeks.Results Compared to aerosol group,the clinical symptom score、inhalation dosage of glucocorticosteroid during remissive period and attack times were significantly lower in nebulising group(P0.05).The compliance was significantly higher than that in aerosol group(t=2.46,P0.05).Conclusion Budesonide inhalation suspension step nebulising inhalation therapy for infant asthma is with high clinical control and high compliance and is convenient and safe,so it deserves to be performed in more patients.