Effect of Rehabilitation on Long-term Efficacy of Botulinum Toxin Type A on Spastic Cerebral Palsy

Objective To investigate the long-term efficacy of Botulinum toxin type A(BTX-A) on spasticity in cerebral palsy,and the effect of rehabilitation on it.Methods 230 children with spastic cerebral palsy were treated with BTX-A block.The dose of BTX-A was identified with the weight of the children and the Modified Ashworth Scale(MAS).They were divided into group A who exercised more than 2 h/d,and group B who exercised less than 2 h/d or not.They were assessed with Gross Motor Function Measure(GMFM) 1 year after treatment.Results There was no significant difference between group A and B with ages,weight,MAS,GMFM before block(P0.05),nor with BTX-A effect time(P0.05).The GMFM improved significantly in both group A and B 1 year after block(P0.05),and it improved more in group A than group B(P0.01).Conclusion The long-term efficacy of BTX-A block is positive.The rehabilitation training after block can help children to improve their gross motor function.