Clinical efficacy of hydroxychloro quine in gout

Objective To observe the impact and safety of hydroxychloroquine(HCQ) on serum uric acid in gout arthritis.Methods 43 rheumatology clinic patients with primary gout who were treated in our hospital during January 2009 to April 2010 were randomly divided into treatment group(26 cases) and control group(20 cases).Treatment group accepted the general treatment,controlling uric acid and hydroxychloroquine.Control group accepted the general treatment,controlling uric acid and small dose of colchicine.Serum uric acid and lipid levels of patients were detected before treatment and after 1,3,6 months of treatment.Results Both groups of patients had significant difference in serum HDL concentration decrease between pretreatment and 3,6 months after treatment(P0.05).At the end of the 3 month,blood TC,LDL,UA levels decreased significantly(P0.05).At the end of the 6 month,blood TC,LDL,UA levels decreased significantly(P0.01).Acute gouty arthritis and reduction of the frequency of recurrence had no significant difference(P0.05).Conclusion HCQ can reduce the number of attacks of gout arthritis and decrease blood uric acid and blood lipids with good tolerability and safety.