The effect of hydroxychloroquine on serum uric acid in patients with gout

Objective To investigate the effect and safety of hydroxychloroquine(HCQ)on serum uric acid(UA)in gout arthritis.Methods Since January 2009 to April 2010,43 rheumatology clinic patients with primary gout were randomly divided into treatment group(25 cases)and control group(18 cases).The patients in treatment group were applied with the general treatment,control of uric acid drugs and hydroxychloroquine;while the patients in the control group was applied with the general treatment,control of uric acid drugs and little dose of colchicine.The serum uric acid and lipid levels was detected and compared before treatment and after 1,3,6 months of treatment,Results(1)Blood UA:Both groups of patients before and after treatment,the end of the 3,6 month had meaningful difference in serum UA concentrations decreased(P0.05, P0.01);at the end of the 3 month and 6 months(P0.05,P0.01).(2)Blood lipid:The blood TC,LDL-C,HDL-C levels improved significantly(P0.05,P0.01),at the end of the 3 months and 6 months,the blood TC,LDL-C,HDL-C levels improved significantly than control group(P0.05,P0.01),acute gouty arthritis and reduce the frequency of recurrence was no significant difference(P0.05)Conclusion HCQ can reduce the number of attacks of gout arthritis and lower blood uric acid,blood lipids,with good tolerability and safety.