The Effects of the Associated Protein and Cell Cycle of Resveratrol with Paclitaxel on Human Gastric Carcinoma Cell Lines in Vitro

Objective:The effect on MGC803 cells from the resveratrol combined with paclitaxel(PA)was studied.Methods:Flow cytometry was applied to study the effectsof the drugs on the cells cycle of the cell lines.Western blot was used to investigate the cytotoxicity of the drugs against human gastric carcinoma cell line in vitro MGC803 individually or in combinations.Results:The growth of the cells stopped at period S.The mitosis and the formation of DNA were res trained.PA significantly decreased the survival level of the cells with Res compared with that used individually,down regulation of Bcl-2,up-regulation of Bax,contribution in nubibus of P-gp.Conclusion:PA could increase the sensitivity of carcinoma cells to kinds of Res,down regulation of Bcl-2,up-regulation of Bax,contribution in nubibus of P-gpand so reduce their side effects.