The Effect of Intensive Therapy on Intima-media Thickness of Carotid or Femoral Arteries and Endothelial Function in Type 2 Diabetes

Objective:To evaluate the effect of intensive therapy of on intima-media thicknes (IMT) of common carotid or femoral arteries and endothelial function in newly diagnosed type 2 diabetes with ultrasonography.Methods:Tontally 111 patients (duration of diagnosis with diabetes≤1 years) without atherosclerosis were designed to undergo the targeted intervention, including the controlling of blood pressure, blood glucose, blood lipid and body weight, and taking aspirin as well. The relationship was evaluated between the status of metabolic control and endothelial function or IMT of common carotid and femoral arteries after one year treatment. Results: The IMT of the carotid artery was significantly less than baseline, flow-mediated dilation(FMD) increased significantly, whereas the IMT of the femoral artery and endothelium-independent dilation had no significant difference between before and after treatment.Conclusion:High-resolution ultrasonography has the advantage of displaying the vascular changes from function to structure in patients with type 2 diabetes. it also can monitor progression or regression of atherosclerosis. High-resolution ultrasonography is useful and convenient in the diagnosis of the vascular diseases in type 2 diabetes.